Search results for " tween 20"

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Deconvolution procedure of the UV-vis spectra. A powerful tool for the estimation of the binding of a model drug to specific solubilisation loci of b…

2015

UV-vis-spectra evolution of Nile Red loaded into Tween 20 micelles with pH and [Tween 20] have been analysed in a non-conventional manner by exploiting the deconvolution method. The number of buried sub-bands has been found to depend on both pH and bio-surfactant concentration, whose positions have been associated to Nile Red confined in aqueous solution and in the three micellar solubilisation sites. For the first time, by using an extended classical two-pseudo-phases-model, the robust treatment of the spectrophotometric data allows the estimation of Nile Red binding constant to the available loci. Hosting capability towards Nile Red is exalted by the pH enhancement. Comparison between bin…

Atomic and Molecular Physics and OpticOxazineAnalytical chemistrySpecific solubilisation lociTween 20PolysorbatesDeconvolutionNile RedMicelleSpectral lineUV-vis spectraAnalytical ChemistrySurface-Active Agentchemistry.chemical_compoundSurface-Active AgentsUltraviolet visible spectroscopycmc; Deconvolution; Nile Red; Specific solubilisation loci; Tween 20; UV-vis spectra; Binding Sites; Oxazines; Polysorbates; Solubility; Spectrophotometry Ultraviolet; Surface-Active Agents; Micelles; Instrumentation; Atomic and Molecular Physics and Optics; Analytical Chemistry; Spectroscopy; Medicine (all)Pulmonary surfactantOxazinesInstrumentationSpectroscopyMicellesAqueous solutionBinding SitesChemistryMedicine (all)Nile redBinding SiteBinding constantAtomic and Molecular Physics and OpticsPolysorbateSolubilitycmcSpectrophotometry UltravioletDeconvolutionMicelle
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“AD HOC” MODIFIED CLAYS FOR BIOTECHNOLOGICAL APPLICATIONS

Nowadays, the scientific community has to face with cogent problems strictly linked to the improvement of quality of live. Among the different tasks to achieve the prefixed objective the focus has been put on the drug administration, i.e., attention has been paid to propose an appropriate solution to improve the performance of a drug delivery system and to eliminate both the side effect and drawbacks. With the aim to achieve the design, synthesis, and characterization of versatile systems, with peculiar characteristics, based on clays and clays modified with a biocompatible surfactant, able to adsorb and release organic substances of pharmaceutical interest the present PhD thesis has been u…

Clays drug delivery systems montmorillonite caolinite sepiolite organoclays tween 20 metronidazole Vitamin A Cinnamic Acid Nile RedArgille sistemi a rilascio modificato del farmaco montmorillonite caoinite sepiolite organoargille tween 20 metrinidazolo Vitamina A acido cinnamico Nile redSettore CHIM/02 - Chimica Fisica
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